Fifteen thiophene-2-yl pyrimidine derivatives were synthesised by a reported procedure. The first step of reaction is\nreacting 2-acetyl thiophene and substituted aromatic aldehydes to prepare chalcones. The second step is preparation of\npyrimidines by reacting guanidine hydrochloride with chalcones. Third step is formation of Schiff base from pyrimidines. Final\nstep is preparation of thiophene-2-yl triazolo pyrimidine derivatives by reacting Schiff base with hydrazine hydrate. Their\nstructures were confirmed by IR, 1H NMR. TLC of synthesized compounds performed in chloroform: ethanol (3:1) solvent\nsystem. The anti-inflammatory activity of all compounds has been recorded on the basis of reference standard indomethacin. All\nthe compounds showed tendency to cause a fall in oedema and showed anti-inflammatory activity. Anti-inflammatory activity of\nall compounds was taken by carrageenan induced rat paw oedema on albino rat.
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